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Article

Polygenic effects of common single-nucleotide polymorphisms on life span: when association meets causality.

Rejuvenation research - 1 Aug 2012

Yashin Anatoliy I, Wu Deqing, Arbeev Konstantin G, Ukraintseva Svetlana V

Abstract excerpt

Recently we have shown that the human life span is influenced jointly by many common single-nucleotide polymorphisms (SNPs), each with a small individual effect. Here we investigate further the polygenic influence on life span and discuss its possible biological mechanisms. First we identified six sets of prolongevity SNP alleles in the Framingham Heart Study 550K SNPs data, using six different statistical...

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Identifiers

PMID: 22533364
DOI: 10.1089/rej.2011.1257
PMCID: PMC3419841

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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