Article
Joint influence of small-effect genetic variants on human longevity.
Aging - 1 Sept 2010
Yashin Anatoliy I, Wu Deqing, Arbeev Konstantin G, Ukraintseva Svetlana V
Abstract excerpt
The results of genome-wide association studies of complex traits, such as life span or age at onset of chronic disease, suggest that such traits are typically affected by a large number of small-effect alleles. Individually such alleles have little predictive values, therefore they were usually excluded from further analyses. The results of our study strongly suggest that the alleles with small individual effects...
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