Article
Isolation and characterization of doxorubicin-resistant Lewis lung carcinoma variants.
Cancer communications - 1 Jan 1990
Bruno N A, Carver L A, Slate D L
Abstract excerpt
A series of drug-resistant variants of the murine Lewis lung carcinoma (3LL-CK) cell line has been isolated using stepwise selection in increasing concentrations of doxorubicin. These variants exhibited classical multidrug resistance as evidenced by decreased doxorubicin accumulation, cross-resis...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Animals
- Cell Division
- Cell Line
- Doxorubicin
- Drug Resistance
- Genetic Variation
- Lung Neoplasms
- Membrane Glycoproteins
- Mice
- Neoplasm Proteins
- Tumor Cells, Cultured
- Verapamil
- Vinblastine