Article
Erythroid cell mitochondria receive endosomal iron by a "kiss-and-run" mechanism.
Biochimica et biophysica acta - 1 Dec 2016
Hamdi Amel, Roshan Tariq M, Kahawita Tanya M, Mason Anne B, Sheftel Alex D, Ponka Prem
Abstract excerpt
In erythroid cells, more than 90% of transferrin-derived iron enters mitochondria where ferrochelatase inserts Fe2+ into protoporphyrin IX. However, the path of iron from endosomes to mitochondrial ferrochelatase remains elusive. The prevailing opinion is that, after its export from endosomes, the redox-active metal spreads into the cytosol and mysteriously finds its way into mitochondria through passive...
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