Article
Genetic features of cerebrospinal fluid-derived subtype B HIV-1 tat.
Journal of neurovirology - 1 Apr 2012
Choi Jun Yong, Hightower George K, Wong Joseph K, Heaton Robert, Woods Steven, Grant Igor, Marcotte Thomas D, Ellis Ronald J, Letendre Scott L, Collier Ann C, Marra Christina M, Clifford David B, Gelman Benjamin B, McArthur Justin C, Morgello Susan, Simpson David M, McCutchan J Allen, Richman Douglas D, Smith Davey M
Abstract excerpt
Since HIV-1 Tat has been associated with neurocognitive dysfunction, we investigated 60 HIV-1 subtype B-infected individuals who were characterized for neurocognitive functioning and had paired CSF and blood plasma samples available. To avoid issues with repeated sampling, we generated population-based HIV-1 tat sequences from each compartment and evaluated these data using a battery of phylogenetic, statistical,...
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