Article
Clade C HIV-1 isolates circulating in Southern Africa exhibit a greater frequency of dicysteine motif-containing Tat variants than those in Southeast Asia and cause increased neurovirulence.
Retrovirology - 8 Jun 2013
Rao Vasudev R, Neogi Ujjwal, Talboom Joshua S, Padilla Ligia, Rahman Mustafizur, Fritz-French Cari, Gonzalez-Ramirez Sandra, Verma Anjali, Wood Charles, Ruprecht Ruth M, Ranga Udaykumar, Azim Tasnim, Joska John, Eugenin Eliseo, Shet Anita, Bimonte-Nelson Heather, Tyor William R, Prasad Vinayaka R
Abstract excerpt
BACKGROUND: HIV-1 Clade C (Subtype C; HIV-1C) is responsible for greater than 50% of infections worldwide. Unlike clade B HIV-1 (Subtype B; HIV-1B), which is known to cause HIV associated dementia (HAD) in approximately 15% to 30% of the infected individuals, HIV-1C has been linked with lower prevalence of HAD (0 to 6%) in India and Ethiopia. However, recent studies report a higher prevalence of HAD in South...
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