Article
Genetic attributes of cerebrospinal fluid-derived HIV-1 env.
Brain : a journal of neurology - 1 Jul 2006
Pillai Satish K, Pond Sergei L Kosakovsky, Liu Yang, Good Benjamin M, Strain Matthew C, Ellis Ronald J, Letendre Scott, Smith Davey M, Günthard Huldrych F, Grant Igor, Marcotte Thomas D, McCutchan J Allen, Richman Douglas D, Wong Joseph K
Abstract excerpt
HIV-1 often invades the CNS during primary infection, eventually resulting in neurological disorders in up to 50% of untreated patients. The CNS is a distinct viral reservoir, differing from peripheral tissues in immunological surveillance, target cell characteristics and antiretroviral penetration. Neurotropic HIV-1 likely develops distinct genotypic characteristics in response to this unique selective...
Topics
- Amino Acid Sequence
- CD4 Lymphocyte Count
- Cerebrospinal Fluid
- Cognition Disorders
- Evolution, Molecular
- Genes, env
- Genetic Variation
- Glycosylation
- HIV Antibodies
- HIV Infections