Article
High frequency of defective vpu compared with tat and rev genes in brain from patients with HIV type 1-associated dementia.
AIDS research and human retroviruses - 1 Apr 2007
Thomas Elaine R, Dunfee Rebecca L, Stanton Jennifer, Bogdan Derek, Kunstman Kevin, Wolinsky Steven M, Gabuzda Dana
Abstract excerpt
Human immunodeficiency virus type 1 (HIV) infection of the central nervous system frequently causes HIV-associated dementia (HAD) and other neurological disorders. The role of HIV regulatory and accessory proteins in the pathogenesis of these disorders is unclear. Here we analyzed sequences of tat, rev, and vpu genes in 55 subgenomic clones previously shown to encode functional env genes from brain and lymphoid...
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