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Article

Neuroimaging abnormalities in clade C HIV are independent of Tat genetic diversity.

Journal of neurovirology - 1 Apr 2017

Paul Robert H, Phillips Sarah, Hoare Jacqueline, Laidlaw David H, Cabeen Ryan, Olbricht Gayla R, Su Yuqing, Stein Dan J, Engelbrecht Susan, Seedat Soraya, Salminen Lauren E, Baker Laurie M, Heaps Jodi, Joska John

Abstract excerpt

Controversy remains regarding the neurotoxicity of clade C human immunodeficiency virus (HIV-C). When examined in preclinical studies, a cysteine to serine substitution in the C31 dicysteine motif of the HIV-C Tat protein (C31S) results in less severe brain injury compared to other viral clades. By contrast, patient cohort studies identify significant neuropsychological impairment among HIV-C individuals...

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Identifiers

PMID: 27913960
DOI: 10.1007/s13365-016-0503-y
PMCID: PMC5334278

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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