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Article

[Optimization and assessment of a reverse hybridization system for the detection of HBV drug-resistant mutations].

Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology - 1 Dec 2011

Liu Yan-chen, Huang Ai-long, Hu Yuan, Hu Jie-li, Lai Guo-qi, Zhang Wen-lu

Abstract excerpt

OBJECTIVE: To establish a detection method for HBV drug-resistant mutations related to lamivudine, adefovir and entecavir by optimization and assessment of reverse hybridization system. METHOD: 26 degenerated probes covering 10 drug-resistant hotspots of 3 drugs were synthesized and immobilized on the same positively charged nylon membrane. PCR products labeled with digoxigenin were hybridized with corresponding...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 22525498
DOI: 10.3760/cma.j.issn.1007-3418.2011.12.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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