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[Drug-resistant genes at hepatitis B virus polymerase region during entecavir treatment].

Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae - 1 Aug 2013

Guo Xiao-feng, Zhang Chao-xian, Liu Yan, Wu Fei, Luo Xin

Abstract excerpt

OBJECTIVE: To investigate the drug-resistant genes at hepatitis B virus (HBV) polymerase region during entecavir (ETV) treatment. METHODS: Serum samples from chronic hepatitis B patients with virologic breakthrough during enticavir therapy were studied. The resistant mutation patterns in the polymerase gene of hepatitis B virus were analyzed using the polymerase chain reaction (PCR)-sequencing method. RESULTS:...

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Identifiers

PMID: 23987494
DOI: 10.3881/j.issn.1000-503X.2013.04.016

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