Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

[Analysis and recombinant construction of HBV the reverse transcriptase gene with drug-resistant mutations from 40 patients with chronic hepatitis B].

Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology - 1 Oct 2009

Su He-ling, Liu Yan, Liu Wen, Zhong Yan-wei, Chen Xue-yuan, Wang Chun-mei, Liu Yong-ming, Xu Dong-ping

Abstract excerpt

OBJECTIVE: To analyze genetic mutation associated with drug resistance in the reverse transcriptase (RT) domain of HBV from 40 patients with chronic hepatitis B, and to construct mutant RT gene recombinant vectors for drug-resistant phenotypic analysis. METHODS: HBV DNA was extracted from sera of the 40 patients receiving anti-HBV nucleot (5) ide analogue. The complete RT domain-encoding gene was amplified by...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antiviral Agents
Share to Cell Line

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cloning, Molecular

Share to Drug Resistance, Viral

Share to Genetic Vectors

Share to Hepatitis B, Chronic

Share to Hepatitis B virus

Share to RNA-Directed DNA Polymerase

Source

Identifiers

PMID: 20387480

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

[Analysis and recombinant construction of HBV the reverse transcriptase gene with drug-resistant mutations from 40 patients with chronic hepatitis B].PMID 20387480Read ↗

[Drug-resistant mutations in hepatitis B virus found in chronic HBV carriers using PCR sequencing technology].Semantic proximity Read ↗

[Mutation analysis of the HBV reverse transcriptase in nucleos(t)ide-treated patients with chronic HBV infection].Semantic proximity Read ↗

Characterization of mutations in the reverse transcriptase region of hepatitis B virus in treated and untreated chronic hepatitis B patients.Semantic proximity Read ↗

[Analysis of risk factors for drug resistant mutations in the reverse transcriptase region in chronic hepatitis B virus-infected patients].Semantic proximity Read ↗

[Construction of whole-genome lamivudine-resistant hepatitis B virus mutant and its replication and expression in HepG2 cells].Semantic proximity Read ↗

[A five-year analysis of HBV mutations in a multidrug-resistant patient with chronic hepatitis B].Semantic proximity Read ↗

[Construction and sequence analysis of recombinant HCV-1b replicon by replacing NS5A region].Semantic proximity Read ↗

Investigation into drug-resistant mutations of HBV from 845 nucleoside/nucleotide analogue-naive Chinese patients with chronic HBV infection.Semantic proximity Read ↗

Characterization of hepatitis B virus reverse transcriptase sequences in Chinese treatment naive patients.Semantic proximity Read ↗

[Multiple-site analysis of HBV drug-resistant mutations in 340 patients with chronic hepatitis B].Semantic proximity Read ↗

[Comparative analysis of drug resistant mutations in the reverse transcriptase domain of hepatitis B virus covalently closed circular DNA and the viral relax circle DNA].Semantic proximity Read ↗

[Tetracycline-inducible replications of wild-type and an adefovir-dipivoxil-resistant hepatitis B virus in human liver cells].Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.