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Article

Optimizing high-resolution melting analysis for the detection of mutations of GPR30/GPER-1 in breast cancer.

Gene - 15 Jun 2012

Aihara Masamune, Yamamoto Shigeru, Nishioka Hiroko, Inoue Yutaro, Hamano Kimikazu, Oka Masaaki, Mizukami Yoichi

Abstract excerpt

G protein-coupled receptor 30/G protein estrogen receptor-1 (GPR30/GPER-1) is a novel membrane receptor for estrogen whose mRNA is expressed at high levels in estrogen-dependent cells such as breast cancer cell lines. However, mutations in GRP30 related to diseases remain unreported. To detect unknown mutations in the GPR30 open reading frame (ORF) quickly, the experimental conditions for high-resolution melting...

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Identifiers

PMID: 22525040
DOI: 10.1016/j.gene.2012.04.029

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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