Article
GPR30 gene polymorphisms are associated with progesterone receptor status and histopathological characteristics of breast cancer patients.
The Journal of steroid biochemistry and molecular biology - 1 Jan 2010
Giess Maria, Lattrich Claus, Springwald Anette, Goerse Regina, Ortmann Olaf, Treeck Oliver
Abstract excerpt
G-protein coupled receptor GPR30 has been demonstrated to mediate estrogenic effects on essential features of human breast cancer cells. Polymorphisms in GPR30 gene might therefore affect breast cancer susceptibility or tumor characteristics. This is the first study examining allele and genotype frequencies of GPR30 single nucleotide polymorphisms (SNPs) in breast cancer patients. A total of 257 sporadic breast...
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