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Article

Hyper-methylation of the upstream CpG island shore is a likely mechanism of GPER1 silencing in breast cancer cells.

Gene - 30 May 2017

Manjegowda Mohan C, Gupta Paridhi Singhal, Limaye Anil M

Abstract excerpt

GPER1, also known as GPR30, is a novel seven-transmembrane G-protein coupled estrogen receptor that mediates both short-term (non-genomic) and long-term (genomic) effects of estrogen in target cells and tissues. A substantial body of work over the last two decades has highlighted its therapeutic or prognostic utility. However, the clinical data on the expression of GPER1 in breast tissue is ambiguous. Analysis of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 28286086
DOI: 10.1016/j.gene.2017.03.006

Genes

GPER1

Provenance

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Hyper-methylation of the upstream CpG island shore is a likely mechanism of GPER1 silencing in breast cancer cells.PMID 28286086Read ↗

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The G Protein-Coupled Estrogen Receptor (GPER) Expression Correlates with Pro-Metastatic Pathways in ER-Negative Breast Cancer: A Bioinformatics AnalysisSemantic proximity Read ↗

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The G-protein-coupled estrogen receptor, a gene co-expressed with ERα in breast tumors, is regulated by estrogen-ERα signalling in ERα positive breast cancer cellsSemantic proximity Read ↗

Optimizing high-resolution melting analysis for the detection of mutations of GPR30/GPER-1 in breast cancer.Semantic proximity Read ↗

GPER deletion triggers inhibitory effects in triple negative breast cancer (TNBC) cells through the JNK/c-Jun/p53/Noxa transduction pathwaySemantic proximity Read ↗

Epigenetic down regulation of G protein-coupled estrogen receptor (GPER) functions as a tumor suppressor in colorectal cancerSemantic proximity Read ↗

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The gene expression of GPER1 is low in fresh samples of papillary thyroid carcinoma (PTC), and in silico analysis.Semantic proximity Read ↗

G Protein-Coupled Estrogen Receptor in Immune Cells and Its Role in Immune-Related DiseasesSemantic proximity Read ↗

The expression of GALNT7, a glycosyltransferase, shows estrogen receptor (ER)-, progesterone receptor (PR)- and HER2-dependent changes in breast cancer with implications in prognosisSemantic proximity Read ↗

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