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Article

Mutation scanning of exon 20 of the BRCA1 gene by high-resolution melting curve analysis.

Clinical biochemistry - 1 Jan 2010

Vorkas Panagiotis A, Christopoulos Konstantinos, Kroupis Christos, Lianidou Evi S

Abstract excerpt

OBJECTIVES: 5382insC frameshift mutation along with 5331G>A (G1738R) missense mutation, both found in exon 20 of the BRCA1 gene, are relatively frequent among the Greek breast and ovarian cancer population (46%). Our goal was to develop a novel, reliable and rapid genotyping/scanning method for mutation detection of the exon 20 of the BRCA1 gene, using high-resolution melting curve analysis. DESIGN AND METHODS:...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19747471
DOI: 10.1016/j.clinbiochem.2009.08.024

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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