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Article

Genetic variants of GPER/GPR30, a novel estrogen-related G protein receptor, are associated with human seminoma.

International journal of molecular sciences - 21 Jan 2014

Chevalier Nicolas, Paul-Bellon Rachel, Camparo Philippe, Michiels Jean-François, Chevallier Daniel, Fénichel Patrick

Abstract excerpt

Testicular germ cell tumors (TGCTs) are the most common solid cancers in young men, with an increasing incidence over several years. However, their pathogenesis remains a matter of debate. Some epidemiological data suggest the involvement of both environmental and genetic factors. We reported two distinct effects of estrogens and/or xeno-estrogens on in vitro human seminoma-derived cells proliferation: (1) an...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Neoplasms, Germ Cell and Embryonal

Share to Receptors, Estrogen

Share to Receptors, G-Protein-Coupled

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Source

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Identifiers

PMID: 24451139
DOI: 10.3390/ijms15011574
PMCID: PMC3907887

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Genetic variants of GPER/GPR30, a novel estrogen-related G protein receptor, are associated with human seminoma.PMID 24451139Read ↗

GPER and Testicular Germ Cell CancerSemantic proximity Read ↗

GPR30, the Non-Classical Membrane G Protein Related Estrogen Receptor, Is Overexpressed in Human Seminoma and Promotes Seminoma Cell ProliferationSemantic proximity Read ↗

Role of GPER-Mediated Signaling in Testicular Functions and TumorigenesisSemantic proximity Read ↗

GPR30 is overexpressed in post-puberal testicular germ cell tumorsSemantic proximity Read ↗

High Levels of Gpr30 Protein in Human Testicular Carcinoma In Situ and Seminomas Correlate with Low Levels of Estrogen Receptor‐Beta and Indicate a Switch in Estrogen ResponsivenessSemantic proximity Read ↗

Estrogen biology: New insights into GPER function and clinical opportunitiesSemantic proximity Read ↗

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