Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

High resolution melting (HRM) analysis for the detection of ER22/23EK, BclI, and N363S polymorphisms of the glucocorticoid receptor gene.

The Journal of steroid biochemistry and molecular biology - 1 Feb 2009

Maltese Paolo, Canestrari Emanuele, Palma Linda, Ruzzo Annamaria, Corini Francesco, Menotta Michele, Andreoni Francesca, Latiano Anna, Annese Vito, Magnani Mauro

Abstract excerpt

Polymorphisms in the glucocorticoid receptor (GR) gene have been associated with altered sensitivity to glucocorticoids. We designed a high-resolution melting (HRM) assay to detect, simultaneously, the three most intriguing GR polymorphisms, selected on the bases of clinical relevance and frequencies in caucasian population as described in literature. HRM enables the detection of ER22/23EK and N363S genotypes but...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Crohn Disease
Share to DNA Mutational Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genotype

Share to Glucocorticoids

Share to Nucleic Acid Denaturation

Share to Polymorphism, Genetic

Share to Polymorphism, Restriction Fragment Length

Share to Receptors, Glucocorticoid

Source

Identifiers

PMID: 19429432
DOI: 10.1016/j.jsbmb.2009.01.012

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

High resolution melting (HRM) analysis for the detection of ER22/23EK, BclI, and N363S polymorphisms of the glucocorticoid receptor gene.PMID 19429432Read ↗

Glucocorticoid resistance in Crohn's disease and ulcerative colitis: an association study investigating GR and FKBP5 gene polymorphisms.Semantic proximity Read ↗

Detection of the Bcl I polymorphism of the glucocorticoid receptor gene by single-tube allele-specific polymerase chain reaction.Semantic proximity Read ↗

Diagnosis of genetic predisposition for lactose intolerance by high resolution melting analysis.Semantic proximity Read ↗

Development of a High-Resolution Melting Approach for Scanning Beta Globin Gene Point Mutations in the Greek and Other Mediterranean Populations.Semantic proximity Read ↗

Characterization of a promoter polymorphism in the glucocorticoid receptor gene and its relationship to three other polymorphismsSemantic proximity Read ↗

High Resolution Melting Analysis is Very Useful to Identify BRCA1 c.4964_4982del19 (rs80359876) Founder Calabrian Pathogenic Variant on Peripheral Blood and Buccal Swab DNA.Semantic proximity Read ↗

Frequencies of Bcl I, E22E, and N363S of h-GR/NR3C1 restriction fragment length polymorphisms of glucocorticoid receptor gene in Polish adult population.Semantic proximity Read ↗

High-throughput genotyping of mannose-binding lectin variants using high-resolution DNA-melting analysis.Semantic proximity Read ↗

High Resolution Melting (HRM) for High-Throughput Genotyping-Limitations and Caveats in Practical Case Studies.Semantic proximity Read ↗

Rapid multiplex high resolution melting method to analyze inflammatory related SNPs in preterm birthSemantic proximity Read ↗

New sequence variants in BRCA1 and BRCA2 genes detected by high-resolution melting analysis in an elderly healthy female population in Croatia.Semantic proximity Read ↗

Optimization of high-resolution melting analysis for simultaneous genotyping of two 11β-hydroxysteroid dehydrogenase type 1 gene polymorphisms.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.