Article
A Model for the Signal Initiation Complex Between Arrestin-3 and the Src Family Kinase Fgr.
Journal of molecular biology - 30 Jan 2022
Perez Ivette, Berndt Sandra, Agarwal Rupesh, Castro Manuel A, Vishnivetskiy Sergey A, Smith Jeremy C, Sanders Charles R, Gurevich Vsevolod V, Iverson T M
Abstract excerpt
Arrestins regulate a wide range of signaling events, most notably when bound to active G protein-coupled receptors (GPCRs). Among the known effectors recruited by GPCR-bound arrestins are Src family kinases, which regulate cellular growth and proliferation. Here, we focus on arrestin-3 interactions with Fgr kinase, a member of the Src family. Previous reports demonstrated that Fgr exhibits high constitutive...
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