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Article

Disruption of foxc1 genes in zebrafish results in dosage-dependent phenotypes overlapping Axenfeld-Rieger syndrome.

Human molecular genetics - 29 Sept 2020

Ferre-Fernández Jesús-José, Sorokina Elena A, Thompson Samuel, Collery Ross F, Nordquist Emily, Lincoln Joy, Semina Elena V

Abstract excerpt

The Forkhead Box C1 (FOXC1) gene encodes a forkhead/winged helix transcription factor involved in embryonic development. Mutations in this gene cause dysgenesis of the anterior segment of the eye, most commonly Axenfeld-Rieger syndrome (ARS), often with other systemic features. The developmental mechanisms and pathways regulated by FOXC1 remain largely unknown. There are two conserved orthologs of FOXC1 in...

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Identifiers

PMID: 32720677
DOI: 10.1093/hmg/ddaa163
PMCID: PMC7530528

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