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Two Systems for Targeted Gene Deletion in Coxiella burnetii

21 Apr 2012

Abstract excerpt

Coxiella burnetii is a ubiquitous zoonotic bacterial pathogen and the cause of human acute Q fever, a disabling influenza-like illness. C. burnetii's former obligate intracellular nature significantly impeded the genetic characterization of putative virulence factors. However, recent host cell-free (axenic) growth of the organism has enabled development of shuttle vector, transposon, and inducible gene expression...

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PMID: 22522687
DOI: 10.1128/aem.00881-12

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