Extended analysis of a genome-wide association study in primary sclerosing cholangitis detects multiple novel risk loci.

doi:10.1016/j.jhep.2012.03.031

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Article

Extended analysis of a genome-wide association study in primary sclerosing cholangitis detects multiple novel risk loci.

Journal of hepatology - 1 Aug 2012

Folseraas Trine, Melum Espen, Rausch Philipp, Juran Brian D, Ellinghaus Eva, Shiryaev Alexey, Laerdahl Jon K, Ellinghaus David, Schramm Christoph, Weismüller Tobias J, Gotthardt Daniel Nils, Hov Johannes Roksund, Clausen Ole Petter, Weersma Rinse K, Janse Marcel, Boberg Kirsten Muri, Björnsson Einar, Marschall Hanns-Ulrich, Cleynen Isabelle, Rosenstiel Philip, Holm Kristian, Teufel Andreas, Rust Christian, Gieger Christian, Wichmann H-Erich, Bergquist Annika, Ryu Euijung, Ponsioen Cyriel Y, Runz Heiko, Sterneck Martina, Vermeire Severine, Beuers Ulrich, Wijmenga Cisca, Schrumpf Erik, Manns Michael P, Lazaridis Konstantinos N, Schreiber Stefan, Baines John F, Franke Andre, Karlsen Tom H

Abstract excerpt

BACKGROUND & AIMS: A limited number of genetic risk factors have been reported in primary sclerosing cholangitis (PSC). To discover further genetic susceptibility factors for PSC, we followed up on a second tier of single nucleotide polymorphisms (SNPs) from a genome-wide association study (GWAS). METHODS: We analyzed 45 SNPs in 1221 PSC cases and 3508 controls. The association results from the replication...

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Identifiers

PMID: 22521342
DOI: 10.1016/j.jhep.2012.03.031
PMCID: PMC3399030

Genes

FUT2
MMEL1
TNFRSF14

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