Article
Genetics of primary sclerosing cholangitis and pathophysiological implications.
Nature reviews. Gastroenterology & hepatology - 1 May 2017
Jiang Xiaojun, Karlsen Tom H
Abstract excerpt
Primary sclerosing cholangitis (PSC) is a chronic disease leading to fibrotic scarring of the intrahepatic and extrahepatic bile ducts, causing considerable morbidity and mortality via the development of cholestatic liver cirrhosis, concurrent IBD and a high risk of bile duct cancer. Expectations have been high that genetic studies would determine key factors in PSC pathogenesis to support the development of...
Topics
- Cholangitis, Sclerosing
- Genetic Predisposition to Disease
- Humans