Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetics of primary sclerosing cholangitis and pathophysiological implications.

Nature reviews. Gastroenterology & hepatology - 1 May 2017

Jiang Xiaojun, Karlsen Tom H

Abstract excerpt

Primary sclerosing cholangitis (PSC) is a chronic disease leading to fibrotic scarring of the intrahepatic and extrahepatic bile ducts, causing considerable morbidity and mortality via the development of cholestatic liver cirrhosis, concurrent IBD and a high risk of bile duct cancer. Expectations have been high that genetic studies would determine key factors in PSC pathogenesis to support the development of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cholangitis, Sclerosing
Share to Genetic Predisposition to Disease
Share to Hepatitis Viruses Studies and Epidemiology

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Liver Disease Diagnosis and Treatment

Share to Liver Diseases and Immunity

Source

Identifiers

PMID: 28293027
DOI: 10.1038/nrgastro.2016.154

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetics of primary sclerosing cholangitis and pathophysiological implications.PMID 28293027Read ↗

Update on primary sclerosing cholangitis genetics.Semantic proximity Read ↗

Immunogenetics in primary sclerosing cholangitis.Semantic proximity Read ↗

Advances and controversies in the pathogenesis and management of primary sclerosing cholangitis.Semantic proximity Read ↗

Genetics in primary sclerosing cholangitis.Semantic proximity Read ↗

A lecture on the genetics of primary sclerosing cholangitis.Semantic proximity Read ↗

Genetics in PSC: what do the "risk genes" teach us?Semantic proximity Read ↗

Genetic epidemiology of primary sclerosing cholangitisSemantic proximity Read ↗

Primary sclerosing cholangitis : from genetic risk to disease biologySemantic proximity Read ↗

The genetic architecture of primary biliary cholangitis.Semantic proximity Read ↗

Primary sclerosing cholangitis.Semantic proximity Read ↗

Genome-wide association study of primary sclerosing cholangitis identifies new risk loci and quantifies the genetic relationship with inflammatory bowel disease.Semantic proximity Read ↗

The Genetics of Primary Biliary Cholangitis: A GWAS and Post-GWAS UpdateSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.