Article
Genetics in PSC: what do the "risk genes" teach us?
Clinical reviews in allergy & immunology - 1 Jun 2015
Folseraas Trine, Liaskou Evaggelia, Anderson Carl A, Karlsen Tom H
Abstract excerpt
A role of genetics in primary sclerosing cholangitis (PSC) development is now firmly established. A total of 16 risk genes have been reported at highly robust ("genome-wide") significance levels, and ongoing efforts suggest that the list will ultimately be considerably longer. Importantly, this genetic risk pool so far accounts for less than 10 % of an estimated overall PSC susceptibility. The relative importance...
Topics
- Animals
- Cholangitis, Sclerosing
- Genetic Association Studies
- Genetic Predisposition to Disease
- Genome-Wide Association Study
- Humans