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Article

Mutation in the platelet-derived growth factor receptor alpha inhibits adeno-associated virus type 5 transduction.

Virology - 20 Jun 2012

Pilz Ingo H, Di Pasquale Giovanni, Rzadzinska Agnieszka, Leppla Stephen H, Chiorini John A

Abstract excerpt

Due to its non-pathogenic lifecycle, little is known about the cellular determinants of infection by adeno-associated virus (AAV). To identify these critical cellular factors, we took advantage of the gene transfer abilities of AAV in combination with a forward genetic selection to identify proteins critical for transduction by this virus. AAV serotype 5 (AAV5) vectors encoding the furin gene were used to...

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Identifiers

PMID: 22520943
DOI: 10.1016/j.virol.2012.03.004
PMCID: PMC3350617

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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