Article
Transduction of human adipose-derived mesenchymal stem cells by recombinant adeno-associated virus vectors.
Tissue engineering. Part C, Methods - 1 Sept 2011
Locke Michelle, Ussher James E, Mistry Raakhi, Taylor John A, Dunbar P Rod
Abstract excerpt
Human adipose-derived stem cells (ASCs) are attractive targets for genetic manipulation and cellular therapies. However, current methods of gene transfer are limited by lack of efficiency, toxicity, or safety concerns. Recombinant adeno-associated virus (rAAV) has been extensively assessed as a gene therapy vector and has an excellent safety profile. This study reports the efficient transduction of...
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