Article
Adenovirus 5-fiber 35 chimeric vector mediates efficient apical correction of the cystic fibrosis transmembrane conductance regulator defect in cystic fibrosis primary airway epithelia.
Human gene therapy - 1 Mar 2010
Granio Ophélia, Ashbourne Excoffon Katherine J D, Henning Petra, Melin Patricia, Norez Caroline, Gonzalez Gaëlle, Karp Philip H, Magnusson Maria K, Habib Nagy, Lindholm Leif, Becq Frédéric, Boulanger Pierre, Zabner Joseph, Hong Saw-See
Abstract excerpt
In vivo gene transfer to the human respiratory tract by adenovirus serotype 5 (Ad5) vectors has revealed their limitations related to inefficient gene transfer, host antiviral response, and innate adenoviral toxicity. In the present work, we compared the cytotoxicity and efficiency of Ad5 and a chimeric Ad5F35 vector with respect to CFTR gene transfer to cystic fibrosis (CF) and non-CF human airway epithelial...
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