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Article

Systemic Vascular Transduction by Capsid Mutant Adeno-Associated Virus After Intravenous Injection.

Human gene therapy - 1 Nov 2015

Lipinski Daniel M, Reid Chris A, Boye Sanford L, Peterson James J, Qi Xiaoping, Boye Shannon E, Boulton Michael E, Hauswirth William W

Abstract excerpt

The ability to effectively deliver genetic material to vascular endothelial cells remains one of the greatest unmet challenges facing the development of gene therapies to prevent diseases with underlying vascular etiology, such as diabetes, atherosclerosis, and age-related macular degeneration. Herein, we assess the effectiveness of an rAAV2-based capsid mutant vector (Y272F, Y444F, Y500F, Y730F, T491V; termed...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26359319
DOI: 10.1089/hum.2015.097
PMCID: PMC4651034

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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