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Efficient Gene Transfer into Human CD34 <sup>+</sup> Cells by a Retargeted Adenovirus Vector

15 Mar 2000

Abstract excerpt

Efficient infection with adenovirus (Ad) vectors based on serotype 5 (Ad5) requires the presence of coxsackievirus-adenovirus receptors (CAR) and alpha(v) integrins on cells. The paucity of these cellular receptors is thought to be a limiting factor for Ad gene transfer into hematopoietic stem cells. In a systematic approach, we screened different Ad serotypes for interaction with noncycling human CD34(+) cells...

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PMID: 10684271
DOI: 10.1128/jvi.74.6.2567-2583.2000

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