Article
BDNF expression in lymphoblastoid cell lines carrying BDNF SNPs associated with bipolar disorder.
Psychiatric genetics - 1 Oct 2012
Gao Yonglin, Galante Mathew, El-Mallakh James, Nurnberger John I, Delamere Nicholas A, Lei Zhenmin, El-Mallakh Rif S
Abstract excerpt
OBJECTIVE: To determine whether single nucleotide polymorphisms (SNPs) of the brain-derived neurotrophic factor (BDNF) that have been associated with bipolar illness are associated with physiological dysfunction. METHODS: Lymphoblastoid cell lines (n=30) obtained from bipolar I individuals carrying zero, one, or two copies of a BDNF SNP associated with bipolar illness (rs12273363) were utilized. RESULTS:...
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