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Article

Genetic variation of brain-derived neurotrophic factor (BDNF) in bipolar disorder: case-control study of over 3000 individuals from the UK.

The British journal of psychiatry : the journal of mental science - 1 Jan 2006

Green Elaine K, Raybould Rachel, Macgregor Stuart, Hyde Sally, Young Allan H, O'Donovan Michael C, Owen Michael J, Kirov George, Jones Lisa, Jones Ian, Craddock Nick

Abstract excerpt

BACKGROUND: Brain-derived neurotrophic factor (BDNF) influences neuronal survival, proliferation and plasticity. Three family-based studies have shown association of the common Valine (Val) allele of the Val66Met polymorphism of the BDNF gene with susceptibility to bipolar disorder. AIMS: To replicate this finding. METHOD: We genotyped the Val66Met polymorphism in our UK White bipolar case-control sample...

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Source

Identifiers

PMID: 16388065
DOI: 10.1192/bjp.bp.105.009969

Genes

BDNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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