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Article

A polymorphism associated with depressive disorders differentially regulates brain derived neurotrophic factor promoter IV activity.

Biological psychiatry - 1 Apr 2012

Hing Benjamin, Davidson Scott, Lear Marrisa, Breen Gerome, Quinn John, McGuffin Peter, MacKenzie Alasdair

Abstract excerpt

BACKGROUND: Changes in brain derived neurotrophic factor (BDNF) expression have been associated with mood disorders and cognitive dysfunction. Transgenic models that overexpress or underexpress BDNF demonstrate similar deficits in cognition and mood. We explored the hypothesis that BDNF expression is controlled by balancing the activity of BDNF promoter IV (BP4) with a negative regulatory region containing a...

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Identifiers

PMID: 22265241
DOI: 10.1016/j.biopsych.2011.11.030
PMCID: PMC3712170

Genes

BDNF

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