Article
Association between STAT1 activity and BRAF mutations in papillary thyroid carcinomas.
Journal of surgical oncology - 1 Nov 2012
Yim Ji Hye, Kim Eun Sook, Choi Hyun-Jung, Jeon Min Ji, Han Ji Min, Kim Won Gu, Kim Tae Yong, Gong Gyungub, Kim Sang Yoon, Kim Won Bae, Shong Young Kee
Abstract excerpt
BACKGROUND: Signal transducer and activator of transcription-1 (STAT1) plays a critical role in tumorigenesis by controlling several functions in both tumor cells and the immune system, and is considered to be a tumor suppressor. The present study evaluated the activity of STAT1 in human papillary thyroid carcinomas (PTC). METHODS: STAT1 activity was measured in nuclear extracts of tumor tissues from 35 PTC...
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