Association between a functional polymorphism rs712 within let-7-binding site and risk of papillary thyroid cancer.

doi:10.1007/s12032-014-0221-3

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Article

Association between a functional polymorphism rs712 within let-7-binding site and risk of papillary thyroid cancer.

Medical oncology (Northwood, London, England) - 1 Oct 2014

Jin Hong, Liang Yundan, Wang Xunli, Zhu Jingqiang, Sun Ruifen, Chen Peng, Nie Xinwen, Gao Linbo, Zhang Lin

Abstract excerpt

KRAS mutation is frequently detected in a series of cancers, including papillary thyroid cancer (PTC). Recently, a genetic variant of rs712 in the 3' untranslated region of the KRAS gene has been reported to be functional in the regulation of KRAS by disrupting complementary site of let-7 and miR-181. We aimed to investigate whether the polymorphism is a risk factor for PTC. We conducted an association study,...

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PMID: 25201577
DOI: 10.1007/s12032-014-0221-3

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KRAS

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Association between a functional polymorphism rs712 within let-7-binding site and risk of papillary thyroid cancer.PMID 25201577Read ↗

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