Article
DUSP5 and DUSP6, two ERK specific phosphatases, are markers of a higher MAPK signaling activation in BRAF mutated thyroid cancers.
PloS one - 1 Jan 2017
Buffet Camille, Hecale-Perlemoine Karine, Bricaire Léopoldine, Dumont Florent, Baudry Camille, Tissier Frédérique, Bertherat Jérôme, Cochand-Priollet Beatrix, Raffin-Sanson Marie-Laure, Cormier Françoise, Groussin Lionel
Abstract excerpt
BACKGROUND: Molecular alterations of the MAPK pathway are frequently observed in papillary thyroid carcinomas (PTCs). It leads to a constitutive activation of the signalling pathway through an increase in MEK and ERK phosphorylation. ERK is negatively feedback-regulated by Dual Specificity Phosphatases (DUSPs), especially two ERK-specific DUSPs, DUSP5 (nuclear) and DUSP6 (cytosolic). These negative MAPK...
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