A trans-ethnic genetic study of rheumatoid arthritis identified FCGR2A as a candidate common risk factor in Japanese and European populations.

doi:10.1007/s10165-011-0467-y

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Article

A trans-ethnic genetic study of rheumatoid arthritis identified FCGR2A as a candidate common risk factor in Japanese and European populations.

Modern rheumatology - 1 Feb 2012

Meziani Roubila, Yamada Ryo, Takahashi Meiko, Ohigashi Kenei, Morinobu Akio, Terao Chikashi, Hiratani Hitomi, Ohmura Koichiro, Yamaguchi Masao, Nomura Takashi, Vasilescu Alexandre, Kokubo Miki, Renault Victor, Hirosawa Katsura, Ratanajaraya Chanavee, Heath Simon, Mimori Tsuneyo, Sakaguchi Shimon, Lathrop Mark, Melchers Inga, Kumagai Shunichi, Matsuda Fumihiko

Abstract excerpt

Rheumatoid arthritis (RA) is a common systemic autoimmune disease and its onset and prognosis are controlled by genetic, immunological, and environmental factors. The HLA locus, particularly HLA-DRB1, is its strongest genetic risk determinant across ethnicities. Several other genes, including PTPN22 and PADI4, show modest association with RA. However, they cover only a part of its genetic components and their...

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Identifiers

PMID: 21607711
DOI: 10.1007/s10165-011-0467-y

Genes

DPYD
PADI4
PTPN22
SPTB

Provenance

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Source receipt: pubmed, retrieved 7 Sept 2026.

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