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Article

Pten regulates Aurora-A and cooperates with Fbxw7 in modulating radiation-induced tumor development.

Molecular cancer research : MCR - 1 Jun 2012

Kwon Yong-Won, Kim Il-Jin, Wu Di, Lu Jing, Stock William A, Liu Yueyong, Huang Yurong, Kang Hio Chung, DelRosario Reyno, Jen Kuang-Yu, Perez-Losada Jesus, Wei Guangwei, Balmain Allan, Mao Jian-Hua

Abstract excerpt

The Aurora-A kinase gene is frequently amplified and/or overexpressed in a variety of human cancers, leading to major efforts to develop therapeutic agents targeting this pathway. Here, we show that Aurora-A is targeted for ubiquitination and subsequent degradation by the F-box protein FBXW7 in a process that is regulated by GSK3β. Using a series of truncated Aurora-A proteins and site-directed mutagenesis, we...

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Source

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Identifiers

PMID: 22513362
DOI: 10.1158/1541-7786.MCR-12-0025
PMCID: PMC3388112

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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