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Article

A genome-wide association study identifies UGT1A1 as a regulator of serum cell-free DNA in young adults: The Cardiovascular Risk in Young Finns Study.

PloS one - 1 Jan 2012

Jylhävä Juulia, Lyytikäinen Leo-Pekka, Kähönen Mika, Hutri-Kähönen Nina, Kettunen Johannes, Viikari Jorma, Raitakari Olli T, Lehtimäki Terho, Hurme Mikko

Abstract excerpt

INTRODUCTION: Circulating cell-free DNA (cf-DNA) is a useful indicator of cell death, and it can also be used to predict outcomes in various clinical disorders. Several innate immune mechanisms are known to be involved in eliminating DNA and chromatin-related material as part of the inhibition of potentially harmful autoimmune responses. However, the exact molecular mechanism underlying the clearance of...

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PMID: 22511988
DOI: 10.1371/journal.pone.0035426
PMCID: PMC3325226

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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