Article
Circulating cell-free DNA in health and disease - the relationship to health behaviours, ageing phenotypes and metabolomics.
GeroScience - 1 Feb 2023
Kananen Laura, Hurme Mikko, Bürkle Alexander, Moreno-Villanueva Maria, Bernhardt Jürgen, Debacq-Chainiaux Florence, Grubeck-Loebenstein Beatrix, Malavolta Marco, Basso Andrea, Piacenza Francesco, Collino Sebastiano, Gonos Efstathios S, Sikora Ewa, Gradinaru Daniela, Jansen Eugene H J M, Dollé Martijn E T, Salmon Michel, Stuetz Wolfgang, Weber Daniela, Grune Tilman, Breusing Nicolle, Simm Andreas, Capri Miriam, Franceschi Claudio, Slagboom Eline, Talbot Duncan, Libert Claude, Raitanen Jani, Koskinen Seppo, Härkänen Tommi, Stenholm Sari, Ala-Korpela Mika, Lehtimäki Terho, Raitakari Olli T, Ukkola Olavi, Kähönen Mika, Jylhä Marja, Jylhävä Juulia
Abstract excerpt
Circulating cell-free DNA (cf-DNA) has emerged as a promising biomarker of ageing, tissue damage and cellular stress. However, less is known about health behaviours, ageing phenotypes and metabolic processes that lead to elevated cf-DNA levels. We sought to analyse the relationship of circulating cf-DNA level to age, sex, smoking, physical activity, vegetable consumption, ageing phenotypes (physical functioning,...
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