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Article

Drug-mediated toxicity caused by genetic deficiency of UDP-glucuronosyltransferases.

Toxicology letters - 15 Mar 2000

Burchell B, Soars M, Monaghan G, Cassidy A, Smith D, Ethell B

Abstract excerpt

Human gene families encoding UDP-Glucuronosyltransferases (UGTs) have been identified and partially characterised. This family of enzymes catalysed the glucuronidation of drugs, xenobiotics and endobiotics. Genetic mutations and polymorphisms have been identified in several UGT genes and examples should be anticipated in all UGT genes. A common genetic defect in the TATA box promoter of the UGT1A1 gene is...

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Source

Identifiers

PMID: 10720749
DOI: 10.1016/s0378-4274(99)00209-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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