Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Circulating Cell-Free Genomic DNA Is Associated with an Increased Risk of Dementia and with Change in Cognitive and Physical Function

23 Aug 2022

Abstract excerpt

BACKGROUND: Altered cell homeostasis, seen in cognitive decline and frailty, leads to cell death and turnover, releasing circulating cell-free DNA (ccf-DNA). OBJECTIVE: The goal of this study is to determine if serum genomic cell-free DNA (ccf-gDNA) is associated with physical and cognitive decline in older adults. METHODS: We used serum from 631 community-dwelling individuals from the Religious Orders Study or...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Genomics and Diagnostics
Share to Epigenetics and DNA Methylation
Share to Ethics in Clinical Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 36031893
DOI: 10.3233/jad-220301

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Circulating Cell-Free Genomic DNA Is Associated with an Increased Risk of Dementia and with Change in Cognitive and Physical FunctionPMID 36031893Read ↗

Cardiovascular-Derived Circulating Cell-Free DNA Fragments Are Associated With Frailty and Increased Cardiovascular Events in Older AdultsSemantic proximity Read ↗

Characterization of the role of distinct plasma cell‐free <scp>DNA</scp> species in age‐associated inflammation and frailtySemantic proximity Read ↗

Epigenetic g predicts cognitive aging and incident dementia in a diverse, nationally representative sample of older adultsSemantic proximity Read ↗

Circulating cell-free DNA in health and disease - the relationship to health behaviours, ageing phenotypes and metabolomics.Semantic proximity Read ↗

Mitochondrial DNA copy number is associated with cognitive function, cognitive decline, and dementia: a longitudinal study in UK BiobankSemantic proximity Read ↗

Association of Mitochondrial DNA Copy Number With Brain MRI Markers and Cognitive FunctionSemantic proximity Read ↗

Associations between circulating cell-free mitochondrial DNA, inflammatory markers, and cognitive and physical outcomes in community dwelling older adultsSemantic proximity Read ↗

5-Hydroxymethylcytosine Signatures in Circulating Cell-Free DNA as Diagnostic Biomarkers for Late-Onset Alzheimer’s DiseaseSemantic proximity Read ↗

Mitochondrial DNA copy number associated dementia risk by somatic mutations and frailty.Semantic proximity Read ↗

Blood-Based mtDNA Quantification Indicates Population-Specific Differences Associated with Alzheimer’s Disease-Related RiskSemantic proximity Read ↗

A standardised methodology for the extraction and quantification of cell-free DNA in cerebrospinal fluid and application to evaluation of Alzheimer’s disease and brain cancersSemantic proximity Read ↗

Clonal Hematopoiesis of Indeterminate Potential and the Risk of Cognitive Impairment in the Women’s Health Initiative Memory StudySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.