Article
Human monoclonal antibodies to a novel cluster of conformational epitopes on HCV E2 with resistance to neutralization escape in a genotype 2a isolate.
PLoS pathogens - 1 Jan 2012
Keck Zhen-yong, Xia Jinming, Wang Yong, Wang Wenyan, Krey Thomas, Prentoe Jannick, Carlsen Thomas, Li Angela Ying-Jian, Patel Arvind H, Lemon Stanley M, Bukh Jens, Rey Felix A, Foung Steven K H
Abstract excerpt
The majority of broadly neutralizing antibodies to hepatitis C virus (HCV) are against conformational epitopes on the E2 glycoprotein. Many of them recognize overlapping epitopes in a cluster, designated as antigenic domain B, that contains residues G530 and D535. To gain information on other regions that will be relevant for vaccine design, we employed yeast surface display of antibodies that bound to genotype...
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