Article
Non-random escape pathways from a broadly neutralizing human monoclonal antibody map to a highly conserved region on the hepatitis C virus E2 glycoprotein encompassing amino acids 412-423.
PLoS pathogens - 1 Aug 2014
Keck Zhen-yong, Angus Allan G N, Wang Wenyan, Lau Patrick, Wang Yong, Gatherer Derek, Patel Arvind H, Foung Steven K H
Abstract excerpt
A challenge for hepatitis C virus (HCV) vaccine development is to define epitopes that are able to elicit protective antibodies against this highly diverse virus. The E2 glycoprotein region located at residues 412-423 is conserved and antibodies to 412-423 have broadly neutralizing activities. However, an adaptive mutation, N417S, is associated with a glycan shift in a variant that cannot be neutralized by a...
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