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Article

Ataxin-1 poly(Q)-induced proteotoxic stress and apoptosis are attenuated in neural cells by docosahexaenoic acid-derived neuroprotectin D1.

The Journal of biological chemistry - 6 Jul 2012

Calandria Jorgelina M, Mukherjee Pranab K, de Rivero Vaccari Juan Carlos, Zhu Min, Petasis Nicos A, Bazan Nicolas G

Abstract excerpt

Neurodegenerative diseases share two common features: enhanced oxidative stress and cellular inability to scavenge structurally damaged abnormal proteins. Pathogenesis of polyglutamine (poly(Q)) diseases involves increased protein misfolding, along with ubiquitin and chaperon protein-containing nuclear aggregates. In spinocerebellar ataxia, the brain and retina undergo degeneration. Neuroprotectin D1 (NPD1) is...

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Identifiers

PMID: 22511762
DOI: 10.1074/jbc.M111.287078
PMCID: PMC3390647

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RPE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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