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Article

DJ-1-dependent regulation of oxidative stress in the retinal pigment epithelium (RPE).

PloS one - 1 Jan 2013

Shadrach Karen G, Rayborn Mary E, Hollyfield Joe G, Bonilha Vera L

Abstract excerpt

BACKGROUND: DJ-1 is found in many tissues, including the brain, where it has been extensively studied due to its association with Parkinson's disease. DJ-1 functions as a redox-sensitive molecular chaperone and transcription regulator that robustly protects cells from oxidative stress. METHODOLOGY: Retinal pigment epithelial (RPE) cultures were treated with H2O2 for various times followed by biochemical and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23844142
DOI: 10.1371/journal.pone.0067983
PMCID: PMC3699467

Genes

RPE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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