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Alterations in the Mitochondrial Proteome of Neuroblastoma Cells in Response to Complex 1 Inhibition

16 Feb 2011

Abstract excerpt

Increasing evidence points to mitochondrial dysfunction in Parkinson's disease (PD) associated with complex I dysfunction, but the exact pathways which lead to cell death have not been resolved. 2D-gel electrophoresis profiles of isolated mitochondria from neuroblastoma cells treated with subcytotoxic concentrations of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), a well-characterized complex I inhibitor,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 21322648
DOI: 10.1021/pr101211k

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