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Article

Inhibition of lipid signaling enzyme diacylglycerol kinase epsilon attenuates mutant huntingtin toxicity.

The Journal of biological chemistry - 15 Jun 2012

Zhang Ningzhe, Li Bensheng, Al-Ramahi Ismael, Cong Xin, Held Jason M, Kim Eugene, Botas Juan, Gibson Bradford W, Ellerby Lisa M

Abstract excerpt

Huntington disease (HD) is a dominantly inherited neurodegenerative disease caused by a polyglutamine expansion in the protein huntingtin (Htt). Striatal and cortical neuronal loss are prominent features of this disease. No disease-modifying treatments have been discovered for HD. To identify new therapeutic targets in HD, we screened a kinase inhibitor library for molecules that block mutant Htt cellular...

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Identifiers

PMID: 22511757
DOI: 10.1074/jbc.M111.321661
PMCID: PMC3375542

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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