Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

PPAR gamma activation is neuroprotective in a Drosophila model of ALS based on TDP-43

28 Nov 2014

Abstract excerpt

Amyotrophic Lateral Sclerosis (ALS) is a progressive neuromuscular disease for which there is no cure. We have previously developed a Drosophila model of ALS based on TDP-43 that recapitulates several aspects of disease pathophysiology. Using this model, we designed a drug screening strategy based on the pupal lethality phenotype induced by TDP-43 when expressed in motor neurons. In screening 1200 FDA-approved...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyotrophic Lateral Sclerosis Research
Share to Cholinesterase and Neurodegenerative Diseases
Share to Neurogenetic and Muscular Disorders Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 25432537
DOI: 10.1093/hmg/ddu587

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

PPAR gamma activation is neuroprotective in a Drosophila model of ALS based on TDP-43PMID 25432537Read ↗

Amyotrophic Lateral Sclerosis Modifiers in Drosophila Reveal the Phospholipase D Pathway as a Potential Therapeutic Target.Semantic proximity Read ↗

Dysregulated FOXO1 activity drives skeletal muscle intrinsic dysfunction in amyotrophic lateral sclerosisSemantic proximity Read ↗

Overexpression of DnaJ chaperones in ameliorating toxicities associated with FUS and TDP-43Semantic proximity Read ↗

PPAR-Delta Agonist Therapies Did Not Rescue Hallmark Disease Phenotypes in Two Sets of Preclinical Trials in ALS TDP-43 and C9orf72 Model Mice.Semantic proximity Read ↗

Cannabidiol ameliorates mitochondrial disease via PPARγ activationSemantic proximity Read ↗

The combination of glycolic acid and D-lactate delays disease progression in SOD-1 ALS mice, partially rescues lethality in iTBPH <sup>pkk(108354)</sup> Drosophila and shows promising results in experimental treatments in two ALS patientsSemantic proximity Read ↗

Genetic validation of a therapeutic target in a mouse model of ALS.Semantic proximity Read ↗

SYF2 suppression mitigates neurodegeneration in models of diverse forms of ALS.Semantic proximity Read ↗

TDP-43 loss-of-function causes neuronal loss due to defective steroid receptor-mediated gene program switching in Drosophila.Semantic proximity Read ↗

Effects of PB‐TURSO on the transcriptional and metabolic landscape of sporadic ALS fibroblastsSemantic proximity Read ↗

Nicotinamide Riboside and Pterostilbene Cooperatively Delay Motor Neuron Failure in ALS SOD1G93A Mice.Semantic proximity Read ↗

Identification of disease-associated molecular signatures in the Prp-TDP-43A315T mouse model of ALS: Toward preclinical biomarker developmentSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.