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Article

Enhanced Akt signaling is an early pro-survival response that reflects N-methyl-D-aspartate receptor activation in Huntington's disease knock-in striatal cells.

The Journal of biological chemistry - 12 Dec 2003

Gines Silvia, Ivanova Elena, Seong Ihn-Sik, Saura Carlos A, MacDonald Marcy E

Abstract excerpt

Huntington's disease features the loss of striatal neurons that stems from a disease process that is initiated by mutant huntingtin. Early events in the disease cascade, which predate overt pathology in Hdh CAG knock-in mouse striatum, implicate enhanced N-methyl-D-aspartate (NMDA) receptor activation, with excitotoxity caused by aberrant Ca2+ influx. Here we demonstrate in precise genetic Huntington's disease...

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Identifiers

PMID: 14522959
DOI: 10.1074/jbc.M309348200

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PDK1
PTEN

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