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Article

Inhibitors of metabolism rescue cell death in Huntington's disease models.

Proceedings of the National Academy of Sciences of the United States of America - 4 Sept 2007

Varma Hemant, Cheng Richard, Voisine Cindy, Hart Anne C, Stockwell Brent R

Abstract excerpt

Huntington's disease (HD) is a fatal inherited neurodegenerative disorder. HD is caused by polyglutamine expansions in the huntingtin (htt) protein that result in neuronal loss and contribute to HD pathology. The mechanisms of neuronal loss in HD are elusive, and there is no therapy to alleviate HD. To find small molecules that slow neuronal loss in HD, we screened 1,040 biologically active molecules to identify...

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Identifiers

PMID: 17726098
DOI: 10.1073/pnas.0704482104
PMCID: PMC1964858

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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